PhD Internship - Molecular Biomarkers of Alzheimer’s Disease for 12 months - RiSE (m/f/d)

Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.

The Position

PhD Internship / RiSE - Molecular Biomarkers of Alzheimer’s Disease (12 months)

The RiSE program (Roche Internships for Scientific Exchange) is a highly competitive student research program at Roche. It offers the most talented postgraduate PhD and medical degree students the opportunity to be fully integrated into our interdisciplinary and international industry R&D environment. As a RiSE student you will enhance your competencies, gain valuable work experience with us, and eventually become part of a world-wide network of RiSE Alumni.

The Neuroscience and Rare Diseases Discovery and Translational Area (NRD DTA) is developing medicines for a range of serious neurological diseases, including multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, autism, spinal muscular atrophy, and Huntington’s disease.

As RiSE student in the NRD DTA you will join our group in Biomarkers, and perform at the Roche Innovation Center Basel, Switzerland, where the successful candidate will analyse omics (biomarkers, genetics, single cell RNA sequencing, etc.) datasets of molecular biomarkers of Alzheimer’s disease to understand the interplay of risk factors in the disease biology and treatment. You will be hosted and mentored by a Roche scientist who will guide you through your research and provide you with the needed work infrastructure and collaborative network.

During the internship your tasks will include:

· Plan and perform cutting-edge bioinformatics and biomarker analyses on large multiomics data sets (genetics, proteomics, single cell RNA sequencing, fluid biomarkers) with the goal of discovering how disease and genetic factors lead to molecular changes in Alzheimer’s disease. Roche has developed an unique repository of longitudinal datasets to which the candidate will have direct access.

· Closely interact with drug development teams to answer key biomarker questions in a live drug development program. The candidate will be exposed to the planning and execution of a randomized clinical trial.

· Summarize your work for internal and external meetings and draft a publication.

Who You Are

You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies. Where a job title is not considered the final definition of who you are, but the starting point.

Moreover you are/have:

· Enrolled in a PhD or medical degree program at a university and are looking to expand your experience with an industry internship (your PhD defense doesn't take place in the first half of the internship)

· Bioinformatician with advanced programming skills in Python, R and experience working with high performance clusters (bash, job queuing).

· Solid understanding of the biology and biomarkers of neurodegeneration and/or Alzheimer’s disease

· Optional: wet-lab experience, in particular, experience in histopathology

· Seeking to closely interact with scientists working at the cutting edge of neuroscience as part of industrial environment

· Entrepreneurial mind set, with a go-getter attitude

· Highly motivated, with a desire to learn about biomarker and drug development.

Information about application documents and start date:

The preferred start date of the internship is summer/ autumn of 2024 or upon availability.

Applications need to include a CV, reference letters, transcripts and a cover letter, as well as a letter from your academic supervisor supporting your application to the RiSE Program.

Please note that due to regulations non-EU/EFTA citizens have to provide a certificate from the university stating that an industry internship is mandatory as part of the university training.

#RiSE

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.