PhD Candidate position to study transcription-replication conflicts and genomic instability
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Veröffentlicht:18 Juli 2025
Pensum:100%
Arbeitsort:Bern
Job-Zusammenfassung
PhD-Stelle an der Universität Bern zur Erforschung von Transkriptions- und Replikationskonflikten. Eine spannende Gelegenheit in einem innovativen Team.
Aufgaben
Untersuchung der molekularen Mechanismen von PARP-Inhibitoren.
Analyse von DNA-Schäden in normalen und Krebszellen.
Anwendung von Techniken wie CRISPR/Cas9 und Next-Generation-Sequencing.
Fähigkeiten
Abschluss eines Masterstudiums oder in den letzten Zügen.
Hintergrund in molekularer und Zellbiologie erforderlich.
Interesse an Krebsbiologie und Genomstabilität von Vorteil.
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PhD Candidate position to study transcription-replication conflicts and genomic instability
University of Bern
WorkplaceBern, Bern region, SwitzerlandCategory
Life Sciences | Health
Position
Junior Researcher / PhD Position
Published17 July 2025
PhD candidate position to study transcription-replication conflicts and genomic instability 100 %
A PhD candidate position is available at the University of Bern, Switzerland, to join the research group of Michalis Petropoulos, in collaboration with Sven Rottenberg (Vetsuisse Faculty and Bern Center for Precision Medicine).
Project Overview: PARP inhibitors are being used to treat human cancers with homologous recombination deficiencies. We recently published on the role of PARP1 in preventing DNA damage in response to transcription-replication conflicts (Petropoulos et al., Nature, 2024).
Aufgaben We are recruiting a PhD candidate to elucidate the molecular mechanisms by which PARPs detect transcription-replication conflicts and act to prevent induction of DNA damage in normal and cancer cells. The successful candidate will be co-supervised by Dr. Michalis Petropoulos, a newly recruited Group Leader at the University of Bern, and Prof. Sven Rottenberg, Director of the Institute of Animal Pathology, University of Bern. Anforderungen Applicants should be in the final stages of their Master’s degree (with expected completion within the next few months) or have completed their degree within the past six months. We are seeking a highly motivated PhD candidate with a background in molecular and cell biology, and a strong interest in cancer biology and genome stability. Experience with techniques such as CRISPR/Cas9, high-content imaging, next-generation sequencing, or organoid models is an advantage but not required. Wir bieten Position Details: Start date: To be discussed, earliest November 1, 2025 Position Details: Salary according to Swiss National Science Foundation (SNSF) guidelines: Annual gross salary: CHF 50’000 - 55’000 Duration: 3 - 4 years Bewerbung und Kontakt How to apply: Please send your application in ONE PdF File to christine.herzig@unibe.ch including:
Your CV
A motivation letter
Names and contact details (or letters) of two academic references
