Computational Intern - Organoid Phenotyping, Institute of Human Biology

Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.

The Position

In Roche Pharmaceutical Research and Early Development Organization (pRED) we believe the rapid advances in science, technology, digital and big data are our greatest opportunity to rethink how we tackle some of the world’s toughest unmet health care needs and to have an even more profound impact on patients and society.

At pRED we are united by our mission to transform science into medicines. Together we create a culture defined by curiosity, responsibility and humility where our amazing people are empowered and inspired to bring forward amazing innovation at speed. Within pRED, the goal of the Institute of Human Biology (IHB) is to disrupt the traditional drug discovery process through innovative, big and bold ideas focused on advancing our ability to use more predictive human model systems.

As a member of the Organoid Phenotyping platform at IHB, you will collaborate with a team of scientists to design and implement computational pipelines for the purpose of analyzing high-content screening data. Your primary responsibility will be the creation of image analysis pipelines capable of processing terabytes of 3D imaging data using the high-performance computing infrastructure provided by Roche. In addition, you will be tasked with developing statistical pipelines to identify and cluster hits and ascertain the signaling pathways that impact the biological processes under investigation. The role also entails collaborating with a team of computer scientists to utilize tools developed at IHB for the processing of large image datasets. This presents a unique opportunity for you to gain hands-on experience with cutting-edge computational tools, thereby enhancing your skills and knowledge. Furthermore, you will work closely with the team to discuss the objectives of the screen, develop pipelines, document code and results, and communicate your findings to both the IHB and the broader Roche community.

Your impact:

• Develop analytical pipelines for large 3D high content imaging datasets

• Develop, document and maintain analytical scripts within the framework of the Imaging Framework at IHB

• Collaborate closely with scientists at IHB for solving their analytical needs.

• Communicate with relevant stakeholders about computational processes. Keep supervisor/project leader informed of the status of the projects and of critical problem areas.

• Provide input for improving computational workflows. Assist supervisor in development, implementation and evaluation of new workflows. Assist with generation of documentation for users and developers.

Your Profile:

• You are currently enrolled in a Master’s degree program or a pursued your Master’s degree not longer than 12 months prior to the start date in Computational Sciences/Life Sciences or related field

• Strong python programming skills

• Experience in image analysis

• Experience in data analytics and data science

• Excellent written and verbal communication skills

• Ability to work independently and as part of a team

• Strong analytical and problem-solving skills

• Experience with microscopy of strong advantage

The preferred start date of the internship is as soon as possible, for 6 months.

Application:

Applications need to include a CV and a motivation letter, both merged in one document. If you are currently studying, p lease include a valid certificate of enrollment as well.

Due to regulations,non-EU/non-EFTA citizenswithout either a B permit with work permitor aC permitneed to provide acertificate of enrollment, as well as acertificate from the university stating that an internship is mandatory and stating the length.

We are excited to see your application!

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.