Senior research officer cell technologies

15.10.2019Position with re­spon­si­bil­i­ties100%

Senior research officer cell technologies

COMPANY OVERVIEW

Glenmark Innovation is a wholly owned subsidiary of Glenmark Pharmaceuticals and is based in the U.S. It has an independent board and a new Chief Executive Officer. The new company will provide an enhanced focus to the Glenmark innovation business and help accelerate the pipeline towards commercialization.

Our Swiss operation encompasses two biological R&D Centers and a GMP manufacturing facility and focuses on the discovery and development of novel biological entities and drugs comprising monoclonal antibodies and proprietary bispecific format in the field of immune-oncology and autoimmune diseases.

Overall we currently have three assets in the clinic in various stages of development from Phase 1 to Phase 2b. We also have multiple discovery programs based on our proprietary technology platform, BEAT® (Bispecific Engagement by Antibodies based on the T cell receptor). Our molecules and drugs under developments target treatment among others of HER2 positive cancers, multiple myeloma and other malignancies of hematopoietic origin, as well as a variety of solid tumors.

We are looking for highly motivated people who thrive on being challenged and working in an agile, collaborative and multicultural environment to join our multidisciplinary discovery team and play a key role in conducting rigorous, cutting-edge science.

To support execution of our ambitious pipeline of projects, we are seeking to hire a

SENIOR RESEARCH OFFICER

CELL TECHNOLOGIES

ROLE OVERVIEW

We invite a motivated and talented scientist with a deep understanding and hands-on experience in molecular biology, cell culture and antibody expression and purification to join an innovative antibody/protein engineering department with a strong record of success in developing novel antibody therapeutics in the field of immune-oncology and autoimmune diseases. You will support mammalian antibody expression platforms and cell-line engineering to facilitate discovery research and advance the next wave of novel therapeutic concepts.

Responsibilities:

  • Lead/participate in cell line engineering activities.
  • Lead antibody expression technologies to select antibodies and bispecific/multispecific antibodies for discovery and support projects.
  • Support vector design and the optimization and characterization of cell lines and cell banks to support stable CHO pool development as a prerequisite to candidate selection for industrialization.

  • Characterize antibody candidates for cell binding using FACS and high-content screening
(HCS) instruments (CellInsight CX5 Platform). - Characterize antibody candidates using biochemical and analytical methods (e.g. SDS-PAGE, SEC, IEF).
  • Present and discuss data in English in both informal and formal settings.
  • Maintain detailed and organized documentation.
  • Participate in day-to-day laboratory management.
  • Perform other relevant duties as required.
  • Collaborate across the matrix to support portfolio development.
  • Comply with HSE guidelines.

Education and Desired Experience:

  • Ph.D. in Molecular Biology, Cell Biology, Biochemistry, or related field with 3 years of relevant industrial experience in a similar role.
  • Proven track record in the following: vector biology, codon optimization, cell line genetic characterization, and vector construction.
  • Experience in stable CHO pool development based on transposons is desired.
  • Strong expertise in mammalian cell culture (small to large scale) and transfection methods.
  • Strong experience with PCR, mutagenesis, DNA handling software, and bioinformatics tools.
  • Knowledge of antibody analytical methods.
  • Excellent time management and organizational skills.
  • Demonstrated ability to work in a multidisciplinary biologics discovery team.
  • Ability to manage multiple priorities and align internal and external stakeholders around these priorities.
  • Fluency in English, both written and verbal is a must have.

Location:

You will join us, a vibrant biotech community at the Biopôle (https://www.biopole.ch/ ) overlooking the beautiful shores of Geneva lake in Lausanne, Switzerland.

Now it is a rare opportunity to join our growing scientific team at the very start of something special. You will become a part of the foundation of a new company making yourself an imprint

Route de la Corniche 5 1066 Epalinges

Info

Info

15.10.2019
Position with re­spon­si­bil­i­ties, 100%
Contact
Route de la Corniche 5 1066 Epalinges

Company

Industry:Chemicals/Pharmaceuticals
Job offers:6 jobs
Location:Chemin de la Combeta 5
2300 La Chaux-de-Fonds
Website:http://www.glenmarkpharma.com
6 jobs — La Chaux-de-Fonds
Salary

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