Computational Biologist

The Schwank Lab is an interdisciplinary team dedicated to advancing genome editing technologies for clinical applications. Over the past years, we have pioneered in vivo genome editing approaches for the treatment of genetic disorders and developed AI-assisted prediction tools to optimize genome editing techniques. Currently, we are engaged in building a next-generation CRISPR tool discovery platform. By integrating AI-assisted protein design, phage-assisted continuous protein evolution, robotics, and high-throughput screening, our platform can rapidly generate and screen billions of CRISPR proteins for specific functions. The overarching goal of this project is to create novel CRISPR tools for correcting currently untreatable genetic diseases.
We are seeking a computational biologist to expand our CRISPR tool discovery platform. Working in an interdisciplinary team of scientists and engineers you will build metagenomic mining pipelines to establish one of the largest CRISPR datasets to date. You will further leverage this data to train foundational protein language models for de novo protein generation.

Computational Biologist

• Develop infrastructure to store and process large amounts of genomic data
• Build scalable pipelines to mine (meta)genomic data
• Create analysis tools to derive actionable insights from directed evolution and screening data
• Build, train, and deploy foundational models for de novo protein generation

Qualifications

• Advanced knowledge of at least one programming language
• Experience in processing, analyzing, and visualizing genomic data
• Good understanding of genetics, microbiology, and molecular biology
• Experience in designing scalable data systems is a plus

Qualities

• Proactive, driven, and high-performing
• Active and independent learner
• Enjoys working closely within an interdisciplinary team
• Excited about the prospects of curing genetic diseases by CRISPR

The University of Zurich is a world-leading institution in biomedical research and the interdisciplinary environment in the Schwank lab will provide opportunities for dynamic and creative work.

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