Research Associate / Scientist Antibody Structural Bioinformatics 100%
Auf einen Blick
- Inserat abgelaufen
- Pensum:100%
- Vertragsart:Festanstellung
- Arbeitsort:Bachtobelstrasse, 8810 Horgen
Numab Therapeutics AG is an expanding, Swiss biotech company based in Horgen, canton of Zürich. The company is focused on the discovery and development of innovative, antibody fragment-based therapeutics with a focus on inflammation and immuno-oncology. With our breakthrough antibody-discovery and multi-specifics engineering platform, we engage in proprietary projects as well as collaborative research on behalf of partners in the pharmaceutical industry.
In this position, you will contribute to identifying best-in-class scFvs and driving Numab’s projects towards development. You will be responsible for sequence and structure analysis for antibody engineering.
Your Responsibilities:
- Perform Sanger/NGS sequence analyses and protein structure modelling using state-of-the-art in-silico methods to gain insights and guide antibody design, selection and optimization
- Analyse in-silico and/or related experimental data sets (for example antibody xray/cryoEM/predicted structures and biophysical data sets)
- Contribute to technology development and innovations
- Develop/expand in-house data processing pipelines
- Prepare and deliver reports and presentations to guide decision-making
- Contribute to publications, conference presentations and patent applications
Ideal candidates will have:
- Deep understanding of antibody/protein structure and solid programming skills
- PhD (preferred) or MSc in computational biology, computational chemistry, theoretical chemistry, biophysical chemistry, biochemistry, chemistry, biophysics, structural biology or a related discipline with relevant industry (preferably biotech) experience
- Experience in molecular modeling, molecular dynamics simulations, docking and structural bioinformatics tools and software (Discovery Studio, Rosetta, or similar) for sequence and structural analysis and structure-based antibody design and optimization
- Substantial experience of working with Unix/Linux at the command-line and writing programs/scripts (e.g., format conversions, report/summary generation, etc.) to solve day-to-day problems
- Proficiency in statistics and able to apply it to analysis of data and results
- Familiarity with high-performance computing environments
- Experience in analysis of large datasets
- Ability to work independently, and willingness to take on tasks and responsibilities as needed in a dynamic cross-functional team environment
- A creative and innovative mindset, with a keen interest in advancing the field of biologics through cutting-edge computational methods
What we offer:
- A diverse field of activities in a dynamic team with an inspiring, entrepreneurial atmosphere.
- Flat hierarchies and expedited decision-making processes.
- The opportunity to take responsibility, help shaping and implementing solutions.
- Attractive employment conditions, superior pension plan, flexible working time model, and opportunities for further personal development.
- Performance-based bonus and participation in the employee stock option plan.
- Several fun team events throughout the year.
- A workplace near the city of Zurich, overlooking the lake.
