PhD in Biomedical Kidney Research (RENAISSANCE Project) 100%

Date de publication :25 novembre 2025
Taux d'activité :100%
Lieu de travail :Bern

Résumé de l'emploi

Le projet RENAISSANCE explore les néphrons sur puce, une innovation en recherche rénale. Une opportunité passionnante pour les chercheurs en biologie et bio-ingénierie.

Tâches

Modéliser les blessures et la réparation des néphrons en culture ex vivo.
Évaluer la viabilité cellulaire et les signaux dans les segments néphroniques connectés.
Collaborer avec l'équipe FHNW pour orienter le développement de la puce.

Compétences

MSc en sciences biomédicales ou domaine connexe requis.
Expérience pratique en culture cellulaire et analyse moléculaire.
Intérêt marqué pour la physiologie rénale et la recherche translationnelle.

Est-ce utile ?

À propos de cette offre

Experimental Nephrology, Department for BioMedical Research
February 2026 (upon agreement)
Employment is fixed for 4 years.
The RENAISSANCE project aims to develop a next-generation nephron-on-a-chip platform that enables the ex vivo recombination of morphologically intact, fully differentiated nephron segments. It addresses a critical unmet need in kidney research - the lack of physiologically relevant, modular in vitro systems that reproduce segment-specific functions and inter-segmental interactions. Current organoid and kidney-on-chip models are limited by developmental immaturity, restricted segmental complexity, and poor reproducibility.

In contrast, RENAISSANCE adopts a top-down approach that preserves native nephron identity and function, establishing a tunable, translationally relevant platform for patient-specific disease modeling, drug screening, and regenerative applications. The project is jointly conducted by Dr. Rudloff (Inselspital Bern) and Dr. Gullo (FHNW), combining complementary expertise in nephrology and disease modeling with biofabrication and microfluidics. Together, the teams aim to establish a physiologically relevant, modular nephron model that bridges the gap between in vitro experimentation and in vivo validation.

PhD focus

The successful candidate will focus on the biological dimension of the project, modeling nephron injury and repair in engineered ex vivo culture, and working at the intersection of biomaterials, disease modeling, and therapeutic interventions.

Key objectives include:

Assessing cell viability, differentiation, and signaling across connected nephron segments

Modeling AKI, nephrotoxicity, and immune-mediated injury using engineered nephron cultures

Investigating protective and regenerative interventions using pharmacological or cellular therapies

Collaborating closely with the FHNW team and provide biological feedback to guide chip development

Your profile

MSc (or equivalent) in biomedical sciences, molecular medicine, cell biology, or related field

Practical experience with mammalian cell culture, microscopy, or molecular analysis

Strong interest in kidney physiology, tissue regeneration, and translational research

Interdisciplinary mindset and motivation to collaborate with biologists, bioengineers, and clinicians

Language proficiency in English and German is an asset

Employment

A vibrant interdisciplinary environment linking clinical nephrology with cutting-edge bioengineering

Access to advanced imaging, molecular, and 3D culture facilities at Inselspital and University of Bern

Close collaboration with the Gullo Lab (FHNW) on translational kidney research

Strong mentorship, interdisciplinary supervision and mentoring within the RENAISSANCE project

Competitive PhD salary according to Swiss university standards

Opportunities for international collaborations, conferences, and publications

Application and contact

For further information about our laboratory and questions regarding the position please contact Dr. Stefan Rudloff, E-Mail schreiben or +41 31 632 96 12.

Please send your application to E-Mail schreiben with the subject line
“PhD Biomedical RENAISSANCE” as a single PDF file, including: