Postdoctoral position in Immunology/Cancer Immunotherapy

Universität Basel

Universität Basel

Bewerben

Auf einen Blick

  • Veröffentlicht:

    30 April 2024

  • Pensum:

    100%

  • Arbeitsort:

    Basel
The Department of Biomedicine is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health and disease and to develop pioneering therapies benefiting the lives of patients in areas of unmet need. With more than 70 research groups and 900 employees, the Department of Biomedicine is the largest department at the University. We are located in the heart of Basel across 6 different locations. Be part of our future!
The research group led by Dr. Prof. Beltra is currently seeking a highly motivated postdoctoral researcher with a strong interest in conducting high level research in the fields of T-cell immunobiology and cancer immunotherapy. This position will be based in the Department of Biomedicine (https://biomedizin.unibas.ch/en/ ) in Basel, Switzerland - one of the world's leading locations for life sciences, home to several companies and institutions.
Prof. Beltra's group is studying the factors governing T-cell differentiation programs in settings of viral infections and cancers. Notably, our group is particularly interested in identifying new pathways regulating the process of CD8 T cell exhaustion, an hypofunctional program acquired by CD8 T cells exposed to persistent inflammation and antigenic stimulation. Indeed, CD8 T cell exhaustion represents a central limitation to current anti-cancer immunotherapies and strategies aiming at reversing this process are still lacking. By exploring the intimate mechanisms regulating CD8 T cell exhaustion, our group aims to identify innovative opportunities to reverse this process and unleash the full potential of current cancer immunotherapies (e.g. PD-1-based therapy). Using state-of-the arts murine models combined to cutting-edge technologies (single cell omics, ATACseq) and innovative immunological and genetic perturbation tools (Retroviruses, CRISPR), our group works on identifying new strategies for a better therapeutic manipulation of exhausted CD8 T cells. Collectively, our group aims to lay the foundation for advancing next-generation cancer immunotherapies.

Your position

  • Planning, designing, and executing experiments including experiments involving mice.
  • Analyzing, structuring, and presenting data.
  • Developing collaborative projects.
  • Mentoring Ph.D. students.
  • Handling mouse colonies and developing original transgenic mouse strains.
  • Participating in common lab tasks.
  • Applying for fellowships and other grants.
  • Preparation of scientific reports, meetings, and journal articles.
  • Communicating science at local and international meetings.

Your profile

  • Ph.D. in Immunology, cancer immunobiology, genetics or related fields.
  • Demonstrated expertise (peer-reviewed publications) in the fields of immunology, T-cell immunobiology, cancer immunobiology and/or cancer immunotherapy - Required
  • Extensive experience in basic immunology techniques (flow cytometry, T-cell based assays) - Required
  • Trained for mouse work (handling, injections, tissue harvest) - Required
  • Demonstrated expertise using CRISPR-based approaches - Required
  • Proficient with basic lab techniques (cell culture, working in sterile conditions).
  • Knowledge in next-generation sequencing techniques and data analysis is considered a plus.
  • Excellent written and communication skills.
  • Fluency in French or English - Required.

We offer you

The successful candidate will have the opportunity to join a young and dynamic group conducting high-level research in immunology. The candidate will be immersed in a vibrant cross-disciplinary and collaborative environment with opportunities for further developing and growing his/her/their scientific interests. Within a supportive and integrative environment, the candidate will benefit from internal trainings in state-of-the-arts immunological techniques (high dimensional flow cytometry), next generation epigenomic approaches (scRNAseq, ATACseq), and access to the large spectrum of technological platforms available at the Department of Biomedicine. Careful mentorship and respect for human values, including diversity, equity, and inclusiveness, are driving forces of our group, ensuring an ideal environment for the candidate to develop, succeed, and plan the next steps of their career. Finally, the University of Basel offers a competitive environment, including attractive salaries, comprehensive social benefits and family-friendly options. 
Application / Contact

Please use the link below to apply and submit the following documents: CV (including list of publications), Cover letter with brief description of past achievements and interests (1 page max), and contact for at least 2 referees including the Ph.D. mentor.
Universität Basel
4001 Basel

Kontakt

  • Universität Basel

Bewerben
In neuem Tab öffnen