Laboratory technician in rapid organism detection through environmental DNA using CRISPR-Cas

The Laboratory of Ecosystems and Landscape Evolution (ELE) and the Genome Engineering and Measurement Lab (GEML) at ETH Zurich are seeking a laboratory technician to join a project developing rapid CRISPR-based environmental DNA (eDNA) detection technologies. The Laboratory of Ecosystem and Landscape Evolution studies the mechanisms that shape biodiversity patterns across spatial and temporal scales and their response to global changes. GEML is a knowledge and technology Hub aimed at syncing the scientific community with rapidly evolving genome engineering methods and techniques. The position is embedded in a collaborative, interdisciplinary effort combining biodiversity research, molecular biology, and engineering, with a strong emphasis in translating scientific innovation into applied environmental solutions. 

The systematic monitoring of living organisms, from pathogens and pests to agricultural species and biodiversity is becoming increasingly important to ensure long-term societal well-being. A major challenge in this field is the early, reliable, and efficient detection of disruptive species (e.g. pests or pathogens), enabling timely intervention and informed management decisions. In this project, we are generating a programmable rapid eDNA detection platform, based on CRISPR-Cas reactions, for fast and cost-effective organism detection across diverse environmental settings.  

• We are building the early foundations of a new venture and are looking for a motivated applicant to join the project at a formative stage.
• The role is designed for someone interested in contributing to the development of a potential spin off, should the project demonstrate traction and should there be strong mutual alignment. 
• The successful candidate will be responsible for collection and processing of eDNA samples from a range of different environments, as well as development, testing, and optimization of molecular reactions and detection methods under both laboratory and field conditions. 
• This includes executing and refining molecular biology workflows, independently troubleshooting experiments, and improving robustness and reproducibility.
• The role further involves supporting the generation of high-quality, reproducible data suitable for intellectual property (IP) development, regulatory pathways and potential commercial use.
• The technician will work closely with the project lead to shape technical direction, set priorities, and iteratively refine the platform. 
• Given the applied nature of the project, the position also requires collaboration with external partners and the ability to communicate clearly with various stakeholders as the project matures and demonstrates scientific and commercial viability.  

Duration: The position is fixed for 12 months (80%). The project is expected to continue within an ETH spin off.

• Master’s degree in molecular biology, biochemistry, biomedical engineering or related fields 
• Hands-on experience with standard molecular laboratory techniques (e.g. DNA/RNA extractions, PCR, qPCR) 
• Experience in method development and testing protocols under laboratory conditions 
• Ability to work independently, plan and document experiments and execute protocols efficiently 
• Strong interest in translating scientific findings into applications, including IP and commercialization 
• Willingness to engage in broader venture-building activities 
• Industrial or product design experience is an advantage 
• Experience with CRISPR-Cas protocols and environmental DNA samples would be a plus 
• Ability to integrate concepts from different disciplines efficiently and adapt to evolving project needs 
• Excellent communication and writing skills (English + one official Swiss language) 

You will work together with a group of scientists (technicians, graduate students, postdocs and senior scientists) to streamline and optimize experimental procedures in the CRISPR/eDNA research domain. The focus will not only be on basic research, but on applied research fields, offering a variety of projects and opportunities to get involved in. You will work in an international vibrant team with the unique opportunity to continuously refine and expand your interpersonal and methodical skills.  

• A stimulating academic environment at one of the world's leading technical universities.
• The opportunity to contribute to impactful projects in favour of biodiversity.
• Work in an international vibrant team with the unique opportunity to continuously refine and expand your interpersonal and methodical skills.

ETH Zurich is one of the world’s leading universities specializing in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.  

Read more about working at ETH and our benefits for employees.

We look forward to receiving your online application with the following documents:

• CV/Resume
• Cover letter explaining your interest and qualifications
• Contact information for 2-3 references

Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

Further information about the Laboratory of Ecosystem and Landscape Evolution can be found on our website . Questions regarding the position should be directed to Prof. Loïc Pellissier (Write an email), no applications.