Principal Scientist - Precision Medicine

About the job

Make your mark for patients

We are looking for a laboratory based Principal Scientist who is innovative and agile to join us in our Translational Research, Precision Medicine group, based in Slough, UK (Windlesham 2027).

About the role

We are looking for a talented Principal Scientist specialized in ligand binding assays and immunoassays (LBA & IA), to join our newly forming Translational Research team alongside the Biomarker Assay Sciences team.

The focus of this role will be to deliver strategic solutions and key translational data to support both clinical biomarker and quantitative pharmacology strategies.

Who you’ll work with

Working closely alongside members of the Biomarker Assay Sciences team, you will gain a breadth of experience across the drug discovery & development pipeline with opportunities to learn and contribute in a scientific and cross-functional setting. Collaborating closely with multidisciplinary Bioanalytical Leads, Biomarker Leads, Research Leads and the broader project team.

What you’ll do

• Deliver high-quality fit-for-purpose ligand binding assay and immunoassay (LBA and IA) solutions to address key translational data requirements.
• Interface closely with multiple diverse disease areas in an agile manner to rapidly understand the underlying biology informing the therapeutic approach of the programmes you are supporting, and present and interpret data at multi-disciplinary project team meetings.
• You will implement scientific strategic understanding to critically consider the context of use of analytical endpoints in order to communicate feasibility and impact on study data interpretation.
• You will represent the team as a Subject Matter Expert in multiple stakeholder interactions: collaboration with various project teams and leadership within matrix teams, and leading CRO interactions to transfer and deliver key assays to deadlines (Contract Research Organisations).
• You will ensure compliance with all Health and Safety regulations, and with the directives of the Human Tissue Act (HTA).

Interested? For this position you’ll need the following education, experience and skills

• PhD. in a biological discipline with 5+ years of relevant experience of LBA and IA bioanalytical assay technologies for translational biomarker data generation, ideally in support of clinical drug development.
• Practical LBA/IA experience in a Pharma/ Biotech or comparable academic setting, with a proven track record in method development and “fit for purpose” assay validation, and in sample and data analysis. (e.g. ELISA, MSD, ELLA, Gyros, Singulex, Simoa/Quanterix, NULISA)
• Demonstrated experience providing solutions for translational biomarker data generation in partnership with multifunctional representation within cross-functional teams.
• Ability to rapidly engage with the biology and underlying pathology of multiple diverse diseases in an agile manner to devise effective strategies, ideally with proven prior experience balancing high need volumes with positioning fit-for-purpose solutions with end-to-end continuity.
• Experience in other analytical techniques such as Flow Cytometry, high-sensitivity targeted LC-MS, IHC, Omic technologies or small-particle analysis (exosomes).
• This is laboratory based position and as such will require 100% on-site attendance.